Assuntos
Pólipos Nasais/complicações , Rinite/sangue , Rinite/complicações , Sinusite/sangue , Sinusite/complicações , Vitamina D/sangue , Adulto , Doença Crônica , Estudos Transversais , Feminino , Humanos , Irã (Geográfico) , Masculino , Índice de Gravidade de Doença , Deficiência de Vitamina D/complicaçõesRESUMO
Nasal polyposis (NP) is a common inflammatory disorder with different proposed etiologies. There is some evidence that the local production of specific IgE against fungal allergens may contribute to the pathogenesis of this condition. The aim of this study was to compare local and systemic production of fungal-specific IgE among patients with NP. In a prospective cross-sectional study, 141 patients with sinonasal polyposis who were surgical candidates were enrolled. Total IgE and fungal-specific IgE antibodies in serum and tissue homogenates were measured by the ELISA and ImmunoCAP method, respectively. Twelve cases (9.45 %) met the allergic fungal rhinosinusitis (AFRS) criteria while the remaining 129 patients showed histopathological features of chronic hyperplastic rhinosinusitis. Considering a cutoff point of 0.4 KUI/L for specific IgE as a positive reaction against fungal elements, seven and 62 cases showed positive results in serum and homogenate tissue, respectively. All serum positive reactions were seen among patients with AFRS. In conclusion, IgE antibody could be locally produced in the nasal polyp tissue while not detectable in the serum.
Assuntos
Alérgenos/sangue , Fungos/imunologia , Imunoglobulina E/sangue , Pólipos Nasais/sangue , Adulto , Alérgenos/imunologia , Estudos Transversais , Feminino , Humanos , Masculino , Pólipos Nasais/imunologia , Estudos ProspectivosRESUMO
A Transmittance band model for IR water vapor in the atmosphere is determined using line by line generated spectra. The absorberp arameters of the model are tabulated.
